Publications
2026
Diaz-Marin R, Hata M, Guber V, De Guire V, Wilson AM, Crespo-Garcia S, Sapieha P. Adipocytes influence choroidal neovascularization via PRDM16. EMBO Mol Med. 2026 Jun;18(6):2379-2403. doi: 10.1038/s44321-026-00441-5. Epub 2026 May 19. PMID: 42156503; PMCID: PMC13269495.
2025
Bellemare G, Micaelo-Fernandes C, Belanger HA, Garon ML, Ptito M, Palmour RM, Crespo-Garcia S, Bouchard JF. Impact of prenatal alcohol exposure in midlife: an assessment of the retina in the vervet monkey. Exp Eye Res. 2025 Nov;260:110638. doi: 10.1016/j.exer.2025.110638. Epub 2025 Sep 10. PMID: 40939857.
Cagnone G, Pundir S, Betus C, Agnihotri T, Ren A, -Kim JS, Harvey NR, Heckel E, Chen MX, Situ A, Gaub P, Kim N, Das A, Leclerc S, Wünnemann F, Berillon L, Andelfinger G, Crespo-Garcia S, Dubrac A, Rezende FA, Clish CB, Maranda B, Rivera JC, Smith LEH, Sapieha P, Joyal JS. Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy. Nat Commun. 2025 Jun 25;16(1):5377. doi: 10.1038/s41467-025-60061-4. PMID: 40562775; PMCID: PMC12198394.
Stürzbecher L, Bartolomaeus H, Bartolomaeus TUP, Bolz S, Sekulic A, Ueffing M, Clark SJ, Reichhart N, Crespo-Garcia S, Wilck N, Strauß O. Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration. Front Immunol. 2025 Feb 5;16:1520188. doi: 10.3389/fimmu.2025.1520188. PMID: 39975545; PMCID: PMC11835843.
2024
Hata M, Hata M, Dejda A, Pilon F, Diaz-Marin R, Fournier F, Joyal JS, Cagnone G, Ochi Y, Crespo-Garcia S, Wilson AM, Sapieha P. Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2411640121. doi: 10.1073/pnas.2411640121. Epub 2024 Dec 18. PMID: 39693344; PMCID: PMC11670060.
🔝 Crespo-Garcia S, Fournier F, Diaz-Marin R, Klier S, Ragusa D, Masaki L, Cagnone G, Blot G, Hafiane I, Dejda A, Rizk R, Juneau R, Buscarlet M, Chorfi S, Patel P, Beltran PJ, Joyal JS, Rezende FA, Hata M, Nguyen A, Sullivan L, Damiano J, Wilson AM, Mallette FA, David NE, Ghosh A, Tsuruda PR, Dananberg J, Sapieha P. Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results. Nat Med. 2024 Feb;30(2):443-454. doi: 10.1038/s41591-024-02802-4. Epub 2024 Feb 6. PMID: 38321220.
Roubeix C, Nous C, Augustin S, Ronning KE, Mathis T, Blond F, Lagouge-Roussey P, Crespo-Garcia S, Sullivan PM, Gautier EL, Reichhart N, Sahel JA, Burns ME, Paques M, Sørensen TL, Strauss O, Guillonneau X, Delarasse C, Sennlaub F. Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration. J Neuroinflammation. 2024 Jan 17;21(1):22. doi: 10.1186/s12974-024-03011-z. PMID: 38233865; PMCID: PMC10792815.
2023
Mawambo G, Oubaha M, Ichiyama Y, Blot G, Crespo-Garcia S, Dejda A, Binet F, Diaz-Marin R, Sawchyn C, Sergeev M, Juneau R, Kaufman RJ, Affar EB, Mallette FA, Wilson AM, Sapieha P. HIF1α-dependent hypoxia response in myeloid cells requires IRE1α. J Neuroinflammation. 2023 Jun 21;20(1):145. doi: 10.1186/s12974-023-02793-y. PMID: 37344842; PMCID: PMC10286485.
Hata M, Hata M, Andriessen EM, Juneau R, Pilon F, Crespo-Garcia S, Diaz-Marin R, Guber V, Binet F, Fournier F, Buscarlet M, Grou C, Calderon V, Heckel E, Melichar HJ, Joyal JS, Wilson AM, Sapieha P. Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life. J Clin Invest. 2023 Feb 15;133(4):e159757. doi: 10.1172/JCI159757. PMID: 36787231; PMCID: PMC9927938.
Hata M, Andriessen EMMA, Hata M, Diaz-Marin R, Fournier F, Crespo-Garcia S, Blot G, Juneau R, Pilon F, Dejda A, Guber V, Heckel E, Daneault C, Calderon V, Des Rosiers C, Melichar HJ, Langmann T, Joyal JS, Wilson AM, Sapieha P. Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation. Science. 2023 Jan 6;379(6627):45-62. doi: 10.1126/science.abj8894. Epub 2023 Jan 5. PMID: 36603072.
Fournier F, Diaz-Marin R, Pilon F, Neault M, Juneau R, Girouard G, Wilson AM, Larrivée B, Mallette FA, Crespo-Garcia S, Sapieha P. Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209973120. doi: 10.1073/pnas.2209973120. Epub 2022 Dec 27. PMID: 36574648; PMCID: PMC9910606.
2021
Diaz-Marin R, Crespo-Garcia S, Wilson AM, Buscarlet M, Dejda A, Fournier F, Juneau R, Alquier T, Sapieha P. Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity. Sci Rep. 2021 Aug 3;11(1):15767. doi: 10.1038/s41598-021-95064-w. PMID: 34344941; PMCID: PMC8333363.
🔝 Crespo-Garcia S, Reichhart N, Kociok N, Skosyrski S, Joussen AM. Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy. Int J Mol Sci. 2021 Apr 25;22(9):4481. doi: 10.3390/ijms22094481. PMID: 33923095; PMCID: PMC8123351.
Andriessen EMMA, Binet F, Fournier F, Hata M, Dejda A, Mawambo G, Crespo-Garcia S, Pilon F, Buscarlet M, Beauchemin K, Bougie V, Cumberlidge G, Wilson AM, Bourgault S, Rezende FA, Beaulieu N, Delisle JS, Sapieha P. Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation. EMBO Mol Med. 2021 May 7;13(5):e11754. doi: 10.15252/emmm.201911754. Epub 2021 Apr 19. PMID: 33876574; PMCID: PMC8103107.
🔝 Crespo-Garcia S, Tsuruda PR, Dejda A, Ryan RD, Fournier F, Chaney SY, Pilon F, Dogan T, Cagnone G, Patel P, Buscarlet M, Dasgupta S, Girouard G, Rao SR, Wilson AM, O’Brien R, Juneau R, Guber V, Dubrac A, Beausejour C, Armstrong S, Mallette FA, Yohn CB, Joyal JS, Marquess D, Beltran PJ, Sapieha P. Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition. Cell Metab. 2021 Apr 6;33(4):818-832.e7. doi: 10.1016/j.cmet.2021.01.011. Epub 2021 Feb 5. PMID: 33548171.
2020
Ménard C, Wilson AM, Dejda A, Miloudi K, Binet F, Crespo-Garcia S, Parinot C, Pilon F, Juneau R, Andriessen EM, Mawambo G, SanGiovanni JP, De Guire V, Sapieha P. miR-106b suppresses pathological retinal angiogenesis. Aging (Albany NY). 2020 Dec 23;12(24):24836-24852. doi: 10.18632/aging.202404. Epub 2020 Dec 23. PMID: 33361521; PMCID: PMC7803573.
Foddis M, Winek K, Bentele K, Mueller S, Blumenau S, Reichhart N N, Crespo-Garcia S, Harnett D, Ivanov A, Meisel A, Joussen A, Strauss O, Beule D, Dirnagl U, Sassi C. An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models. J Cereb Blood Flow Metab. 2020 Feb;40(2):276-287. doi: 10.1177/0271678X19827251. Epub 2019 Feb 7. PMID: 31549895; PMCID: PMC7370619.
🔝 Binet F, Cagnone G, Crespo-Garcia S, Hata M, Neault M, Dejda A, Wilson AM, Buscarlet M, Mawambo GT, Howard JP, Diaz-Marin R, Parinot C, Guber V, Pilon F, Juneau R, Laflamme R, Sawchyn C, Boulay K, Leclerc S, Abu-Thuraia A, Côté JF, Andelfinger G, Rezende FA, Sennlaub F, Joyal JS, Mallette FA, Sapieha P. Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science. 2020 Aug 21;369(6506):eaay5356. doi: 10.1126/science.aay5356. PMID: 32820093.
2019
🔝 Crespo-Garcia S, Reichhart N, Wigdahl J, Skosyrski S, Kociok N, Strauß O, Joussen AM. Lack of netrin-4 alters vascular remodeling in the retina. Graefes Arch Clin Exp Ophthalmol. 2019 Oct;257(10):2179-2184. doi: 10.1007/s00417-019-04447-3. Epub 2019 Aug 26. doi: 10.1007/s00417-019-04539-0. PMID: 31451908.
Diaz Marin R, Crespo-Garcia S, Wilson AM, Sapieha P. RELi protocol: Optimization for protein extraction from white, brown and beige adipose tissues. MethodsX. 2019 Apr 18;6:918-928. doi: 10.1016/j.mex.2019.04.010. PMID: 31080756; PMCID: PMC6500908.
Miloudi K, Oubaha M, Ménard C, Dejda A, Guber V, Cagnone G, Wilson AM, Tétreault N, Mawambo G, Binet F, Chidiac R, Delisle C, Buscarlet M, Cerani A, Crespo-Garcia S, Bentley K, Rezende F, Joyal JS, Mallette FA, Gratton JP, Larrivée B, Sapieha P. NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4538-4547. doi: 10.1073/pnas.1814711116. Epub 2019 Feb 20. PMID: 30787185; PMCID: PMC6410871.
2018
Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O. Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). PLoS One. 2018 Mar 16;13(3):e0193961. doi: 10.1371/journal.pone.0193961. PMID: 29547662; PMCID: PMC5856268.
Brockmann C, Dege S, Crespo-Garcia S, Kociok N, Brockmann T, Strauß O, Joussen AM. Spatial distribution of CD115+ and CD11b+ cells and their temporal activation during oxygen-induced retinopathy in mice. Graefes Arch Clin Exp Ophthalmol. 2018 Feb;256(2):313-323. doi: 10.1007/s00417-017-3845-0. Epub 2017 Nov 28. PMID: 29185100.
2017
🔝 Crespo-Garcia S, Corkhill C, Roubeix C, Davids AM, Kociok N, Strauss O, Joussen AM, Reichhart N. Inhibition of Placenta Growth Factor Reduces Subretinal Mononuclear Phagocyte Accumulation in Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):4997-5006. doi: 10.1167/iovs.16-21283. PMID: 28979997.
Reichhart N, Crespo-Garcia S, Haase N, Golic M, Skosyrski S, Rübsam A, Herrspiegel C, Kociok N, Alenina N, Bader M, Dechend R, Strauss O, Joussen AM. The TetO rat as a new translational model for type 2 diabetic retinopathy by inducible insulin receptor knockdown. Diabetologia. 2017 Jan;60(1):202-211. doi: 10.1007/s00125-016-4115-0. Epub 2016 Oct 4. PMID: 27704165.
2016
Reichhart N, Haase N, Crespo-Garcia S, Skosyrski S, Herrspiegel C, Kociok N, Fuchshofer R, Dillinger A, Poglitsch M, Müller DN, Joussen AM, Luft FC, Dechend R, Strauß O. Hypertensive retinopathy in a transgenic angiotensin-based model. Clin Sci (Lond). 2016 Jul 1;130(13):1075-88. doi: 10.1042/CS20160092. Epub 2016 Mar 29. PMID: 27026533.
Kociok N, Crespo-Garcia S, Liang Y, Klein SV, Nürnberg C, Reichhart N, Skosyrski S, Moritz E, Maier AK, Brunken WJ, Strauß O, Koch M, Joussen AM. Lack of netrin-4 modulates pathologic neovascularization in the eye. Sci Rep. 2016 Jan 6;6:18828. doi: 10.1038/srep18828. PMID: 26732856; PMCID: PMC4702134.
2015
Crespo-Garcia S, Reichhart N, Hernandez-Matas C, Zabulis X, Kociok N, Brockmann C, Joussen AM, Strauss O. In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization. Exp Eye Res. 2015 Oct;139:13-21. doi: 10.1016/j.exer.2015.07.012. Epub 2015 Jul 26. PMID: 26213305.
